Research Publications: Recent submissions

Now showing items 1-20 of 5753

Cytokines in HIV-1 patients on combination antiretroviral therapy with persistent low-level viremia at a tertiary hospital in Western Kenya

Undisa, Rose; Ndede, Isaac; Diero, Lameck Oteko (Pan African medical journal, 2025-05-21)

Introduction: persistent low-level viremia (pLLV) in HIV-1 participants on combination antiretroviral therapy (cART) is a significant predictor of immune activation and virologic rebound. Elevated cytokine levels are ...
Machine learning of blood haemoglobin and haematocrit levels via smartphone conjunctiva photography in Kenyan pregnant women: a clinical study protocol

Sakthivel, Haripriya; Park, Sang Mok; Kwon, Semin; Kaguiri, Eunice; Nyaranga, Elizabeth; Leem, Jung Woo; Hong, Shaun G; Lane, Peter J; Were, Edwin O; Were, Martin C; Kim, Young L (BMJ Open, 2015-04-23)

Introduction Anaemia during pregnancy is a widespread health burden globally, especially in low- and middle- income countries, posing a serious risk to both maternal and neonatal health. The primary challenge is ...
Prevalence of Disseminated Tuberculosis in Human Immunodeficiency Virus Infected Persons Admitted with Sepsis at a Tertiary Hospital in Western Kenya

C, Gituku; A, Gardner; L, Diero; M, Karoney; C, Kanyoru; A, Salim (oaskpublishers.com, 2025-03-04)

Background: The current burden of disseminated Tuberculosis in adult Persons Living with Human Immunodeficiency Virus (PLHIV) is unknown in western Kenya. LF LAM is the only test found to have a mortality benefit. Objectives: ...
Peer Navigation for HIV-Associated Kaposi Sarcoma in Kenya: The Power of the Survivor’s Voice

Shiravika, Fredrick; Strahan, Alexis G.; Zehtab, Morvarid; Chemtai, Linda; Lagat, Celestine; Mulanda, Emily; Collier, Sigrid M.; Rotich, Elyne; Maurer, Toby; Martin, Jeff; Opakas, Jesse; Byakwaga, Helen; Semeere, Aggrey; Kiprono, Samson; Freeman, Esther E. (American Society of Clinical Oncology, 2025-03-20)

PURPOSE Sub-Saharan Africa bears a disproportionate share of the global burden of HIV- associated Kaposi’s sarcoma (KS), with high morbidity and mortality rates influenced by stigma, delayed diagnosis, and limited access ...
Evaluation of pathology resources for cervical cancer detection between 2018 and 2022: a retrospective study at Moi Teaching and Referral Hospital, Western Kenya

Anangwe, Nelson; Steimgrimson, Jon; Cu-Uvin, Susan (BMC Cancer, 2025-02-05)

Background Cervical cancer cases are increasing in sub-Saharan Africa, particularly in Kenya, exacerbated by inadequate histopathology resources, posing a significant barrier to timely diagnosis and treatment. There has ...
Readiness of primary healthcare and community markets for joint delivery of cardiovascular disease prevention services in Kenya: an observational feasibility study of Health Kiosks in Markets (HEKIMA)

Kaduka, Lydia; Olale, Joanna; Mutai, Joseph; Christelle, Elia; Mbuka, Jaymima; Ochieng, Rodgers; Oyugi, Boniface; Oduor, Chrispine; O’Keeffe, Majella; Boulding, Harriet; Murdoch, Jamie; Parmar, Divya; Kokwaro, Gilbert; Ogola, Elijah; Cruickshank, John Kennedy; Muniu, Erastus; Harding, Seeromanie (BMJ open, 2024-11-20)

Objectives The increasing burden of cardiovascular diseases (CVDs) in Kenya threatens its healthcare system. There is a need for innovative models that improve equitable access to CVD prevention services. Community markets ...
Effects of a single oral dose of azithromycin in laboring women on antimicrobial resistance (AMR) and the microbiome: a protocol for the Antimicrobial Resistance Sub-Study of the A-PLUS trial

Kim, Jean H.; Babineau, Denise; Moore, Janet L.; Subramaniam, Akila; Tita, Alan; Chomba, Elwyn; Mwenchanya, Musaku; Lokangaka, Adrien; Tshefu, Antoinette; Patel, Archana; Das, Prabir; Goudar, Shivaprasad S.; Tikmani, Shiyam Sunder; Ahmed, Imran; Saleem, Sarah; Esamai, Fabian; Mazariegos, Manolo; Billah, Sk Masum; Haque, Rashidul; Goldenberg, Robert L.; Bauserman, Melissa; Bucher, Sherri; Krebs, Nancy F.; Derman, Richard J.; Petri Jr, William A.; Thomas, Marion Koso-; Foday, Jennifer J. Hemingway-; Aceituno, Anna; McClure, Elizabeth M.; Ward, Doyle V.; Leal, Sixto; Carlo, Waldemar A.; Hibberd, Patricia L. (Gates open research, 2025-02-05)

Background The Azithromycin Prevention in Labor Use Study (A-PLUS), a large, multi-national randomized trial, was performed to evaluate the improvement of maternal and newborn outcomes following a single dose of ...
Effectiveness of intrapartum azithromycin to prevent infections in planned vaginal births in low-income and middle-income countries: a post-hoc analysis of data from a multicentre, randomised, double-blind, placebo-controlled trial

Carlo, Waldemar A; Janet, Alan T N Tita; Moore, Janet L; Mwenechanya, Musaku; Chomba, Elwyn; Foday, Jennifer J Hemingway-; Kavi, Avinash; Metgud, Mrityunjay C; Goudar, Shivaprasad S; Derman, Richard J; Lokangaka, Adrien; Tshefu, Antoinette; Bauserman, Melissa; Patterson, Jackie K; Shivkumar, Poonam; Waikar, Manju; Patel, Archana; Hibberd, Patricia L; Nyongesa, Paul; Esamai, Fabian; Ekhaguere, Osayame Austine; Bucher, Sherri; Jessani, Saleem; Tikmani, Shiyam Sunder; Saleem, Sarah; Goldenberg, Robert L; Billah, Sk Masum; Lennox, Ruth; Haque, Rashidul; Petri, William; Mazariegos, Manolo; Krebs, Nancy F; Babineau, Denise C; McClure, Elizabeth M; Thomas, Marion Koso- (The Lancet Global Health, 2025-06-04)

Background In 2023, the Azithromycin Prevention in Labor Use (A-PLUS) trial showed intrapartum azithromycin reduces maternal sepsis or death in women with planned vaginal delivery in low-resource settings, but whether ...
Cost-effectiveness of intrapartum azithromycin to prevent maternal infection, sepsis, or death in low-income and middle-income countries: a modelling analysis of data from a randomised, multicentre, placebo-controlled trial

Patterson, Jackie K; Neuwahl, Simon; Kirsch, Sydney; L Moore, Janet; Tita, Alan T N; Carlo, Waldemar A; Lokangaka, Adrien; Tshefu, Antoinette; Mwenechanya, Musaku; Chomba, Elwyn; Kavi, Avinash; Metgud, Mrityunjay C; Goudar, Shivaprasad S; Derman, Richard J; Shivkumar, Poonam; Waikar, Manju; Patel, Archana; Hibberd, Patricia L; Nyongesa, Paul; Esamai, Fabian; Ekhaguere, Osa A; Bucher, Sherri; Jessani, Saleem; Tikmani, Shiyam S; Saleem, Sarah; Wylie, Blair J; Goldenberg, Robert L; Billah, Sk Masum; Lennox, Ruth; Haque, Rashidul; Petri, William A; Mazariegos, Manolo; Krebs, Nancy F; Foday, Jennifer J Hemingway-; Babineau, Denise; Thomas, Marion Koso-; McClure, Elizabeth M; Bauserman, Melissa (Elsevier, 2025-03-28)

Background Sepsis is one of the leading causes of maternal mortality globally. In 2023, the Azithromycin Prevention in Labor Use (A-PLUS) trial showed intrapartum azithromycin for women planning a vaginal birth reduced ...
Low systemic IFN response and high viral load are associated with COVID-19 disease severity in unvaccinated patients in Kenya, 2022-2023

Ayako, Rebeccah M.; Patel, Kirtika; I Ndede, saac; Mining, Simeon K.; Jonas, Klingström; Nordgren, Johan; Larsson, Marie (authorea.com, 2025-06-19)

Cellular and humoral responses, as well as virus replication kinetics, may affect the severity of COVID-19. This study examined systemic and mucosal immune responses as well as viral load in unvaccinated SARS-CoV-2 ...
HIV drug resistance, early treatment outcomes and impact of guidelines compliance after protease inhibitor-based second-line failure in a dedicated resistance clinic in western Kenya: a retrospective cohort study

Humphrey, John M.; Ali, Shamim M.; DeLong, Allison; Novitsky, Vlad; Sang, Edwin; Jawed, Bilal; Kemboi, Emmanuel; Ngetich, Celia; Goodrich, Suzanne; Gardner, Adrian; Hogan, Joseph W.; Kantor, Rami (Journal of the International AIDS Society, 2025-05-26)

Introduction: Data on drug resistance, viral outcomes and guidelines compliance following protease inhibitor (PI)-based second-line failure in low- and middle-income countries are limited, particularly in the era of ...
Piloting the extension for community healthcare outcomes (ECHO) pediatric oncology elehealth education program in western Kenya:iImplementation study

Severance, Tyler; Olbara, Gilbert; Njuguna, Festus; Kipng'etich, Marth; Lang'at, Sandra; Kugo, Maureen; Lemmen, Jesse; Treff, Marjorie; Loehre, Patrick; Vik, Terry (Pubmedcentral, 2025-06-03)

Background: Childhood cancer has an annual incidence of 150‐160 cases per million children worldwide but remains vastly underdiagnosed in low- to middle-income countries such as those in Sub-Saharan Africa. The Moi Teaching ...
A socioecological examination of father alcohol use in Kenya: Motivation, consequences, and barriers to care

Giusto, Ali; Satinsky, Emily N.; Jaguga, Florence; Rono, Wilter; Barasa, Julius; Galán, Chardée A.; Wainberg, Milton L. (GLOBAL PUBLIC HEALTH, 2025-05-31)

ABSTRACT Fathers’ alcohol use impacts family well-being, including increased risk for violence, poor child outcomes, and low engagement in care. Yet few studies examine the drivers of alcohol use among fathers or the ...
Characteristics and associated survival of patients diagnosed with non–small cell lung cancer in a designted lung cancer program in western Kenya

Busakhala, Naftali; Atundo, Lawrence; Kiprono, Hillary; Keitany, Kibet; Melly, Elias; Ruto, Ruth; Wanja, Madrine; Chepsiror, Daniel; Rangoonwala, Hussain; Kipchirchir, Cornelius; Chesori, Erick; Oguda, John; Opakas, Jesse; Loehrer, Patrick J.; Diero, Lameck; Morgan, Jennifer (American Society of Clinical Oncology, 2025-05-04)

Original Reports | Thoracic Oncology Characteristics and Associated Survival of Patients Diagnosed With Non–Small Cell Lung Cancer in a Designated Lung Cancer Program in Western Kenya Naftali Busakhala, MBChB1,2,3 ; ...
Antibiotic use in infants in the 6 weeks after delivery in seven low- and middle-income countries: findings from the A-PLUS trial

Yasmin, Haleema; Tanveer, Saba; Tikmani, Shiyam Sunder; Shakeel, Janet L.; Shakeel, Iram; Rahim, Anum; Lokangaka, Adrien; Tshefu, Antoinette; Bauserman, Melissa; Mwenechanya, Musaku; Chomba, Elwyn; Goudar, Shivaprasad S.; Kavi, Avinash; Derman, Richard J.; Krebs, Nancy F.; Figueroa, Lester; Mazariegos, Manolo; Nyongesa, Paul; Bucher, Sherri; Esamai, Fabian; Patel, Archana; Waikar, Manjushree; Shivkumar, Poonam; Hibberd, Patricia L.; Petri, William A.; Billah, Sk Masum; Haque, Rashidul; Carlo, Waldemar A.; Tita, Alan; Thomas, Marion Koso-; Foday, Jennifer Hemingway-; Saleem, Sarah; McClure, Elizabeth M.; Goldenberg, Robert L. (Taylor & Francis Group, 2024-10-27)

Objectives: Antibiotic use is increasing in low- and middle-income countries (LMIC); however, few studies have examined the rates of use in a population. The use of antibiotics for liveborn infants in LMIC was ...
Effects on maternal and pregnancy outcomes of first-trimester malaria infection among nulliparous women from Kenya, Zambia, and the Democratic Republic of the Congo

LeubaI, Sequoia I.; Westreich, Daniel; Bose, Carl L.; Olshan, Andrew F.; Taylor, Steve M.; Tshefu, Antoinette; Lokangaka, Adrien; Carlo, Waldemar A.; Chomba, Elwyn; Mwenechanya, Musaku; Liechty, Edward A.; BucherI, Sherri L.; Ekhaguere, Osayame A.; Esamai, Fabian; Nyongesa, Paul; Jessani, Saleem; Saleem, Sarah; Goldenberg, Robert L.; Moore, Janet L.; Nolen, Tracy L.; Foday, Jennifer Hemingway-; McClure, Elizabeth M.; Thomas, Marion Koso-; Derman, Richard J.; Hoffman, Matthew; Meshnick, Steven R.; Bauserman, Melissa (PLOS ONE, 2024-12-20)

Background Few studies have assessed the impact of first-trimester malaria infection during pregnancy. We estimated this impact on adverse maternal and pregnancy outcomes. Methods In a convenience sample of women from ...
Patterns, treatment modalities and outcomes of extremity fractures in children presenting at Moi Teaching and Referral Hospital, Eldoret Kenya

Wabuge, Kisiangani Paul; Ayumba, Barry Ramadhani; Ndulu, Kilonzo; Mwangi, Henry R (International Journal of Scientific and Research Publications, 2025-03)

- Background: Fractures in children mostly from unintentional injuries represent a major public health concern, and 90% occur in low- medium income countries. The prevalence of extremity fractures in children is increasing; ...
A qualitative study on the challenges of clinical leadership in an HIV care system: insights from healthcare providers in eldoret, Kenya

Cherop, Felishana; Korir, Michael; Bagire, Vincent; Kimwolo, Andrew; Naanyu, Violet; Wachira, Juddy (Frontiers, 2025-05-14)

Introduction: The provision of quality services to patients in healthcare facilities requires effective clinical leaders who will transcend their technical expertise and coordinate and direct patient care through clinical ...
Perception of medical students towards studying neurosurgery in Kenya: a mixed methods study

Ojakapeli, Ben; Seltzer, Laurel; Karani, Mercy G.N.; Emojong, Ednah Brook; Matata, Kavulavu Briton; Chaina, Brian; Samoe, Noah; Jebet, Chenger June; Nyambega, Silas; Limo, Ian Kipkorir; Omondi Oluoch, George Bryan; Nambiro, Angela; Lotodo, Teresa; Ayumba, Barry; Radwanski, Ryan (Thieme, 2025-05-23)

Objective Neurosurgery, a highly demanding and vital medical specialty, faces significant challenges in sub-Saharan Africa, where a shortage of trained neurosur- geons persists. This study aimed to explore the perceptions ...
Blood loss and transfusion during open femur fracture surgeries at moi teaching and referral hospital, eldoret, Kenya

Njoroge, Cyrus Ng’ang’a; Ramadhan, Ayumba Barry; Cherop, Lotodo Teresa (Scientific Research Publishing Inc., 2024-06-15)

Fractures of the femur due to increased road traffic accidents are on the rise and lead among orthopedic trauma conditions at Moi Teaching and Referral Hospital (MTRH). The best treatment is open surgery with fixation ...

Now showing items 1-20 of 5753

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