Abstract:
Introduction: By 2023, HIV will have claimed 40.4 million lives, posing a
significant global public health risk, with youth at the highest risk of new
infections. Pre-exposure prophylaxis (PrEP) reduces HIV transmission by 48.9%
when combined with other prevention strategies. Despite increased PrEP
programs in sub-Saharan Africa since 2015, uptake remains low due to various
barriers. This study aims to validate a model identifying demographic, economic,
social, behavioral, and structural factors influencing PrEP use in Turbo Sub-
County, where uptake is among the lowest.
Methods: The study will employ a descriptive cross-sectional design using both
quantitative and qualitative methods to gather data from youths aged 15–24 in
Turbo Sub-County. Participants will be selected through multistage random
sampling based on Wards and villages. Data will be collected via self-
administered questionnaires, interviews, and Focus Group Discussions (FGDs).
Analysis will include thematic methods for qualitative data and Structural
Equation Modeling (SEM) will be used to validate the relationships predicting
PrEP uptake at 95% confidence intervals and a < 0.05.
Results: The study is expected to provide insights into factors influencing PrEP
uptake among youths in Turbo Sub-County. The validated model will highlight
key demographic, economic, and behavioral determinants, offering actionable
data for enhancing HIV prevention strategies tailored to this population.
Discussion: The discussion will interpret the interplay of factors affecting PrEP
uptake and compare findings with regional studies. It will emphasize community-
specific barriers and enablers, informing targeted interventions and strategies to
improve PrEP accessibility and acceptance.Conclusions: The study aims to provide a validated framework for predicting
PrEP uptake, guiding stakeholders in addressing barriers and strengthening
interventions. The findings will support optimizing PrEP programs to reduce
HIV transmission among at-risk youth.
